Top 40 Hits of Early October 2000
 | 1 | Mariah Carey & Westlife | Against All Odds |
 | 2 | Zombie Nation | Kernkraft 400 |
 | 3 | The Architechs featuring Nana | Body Groove |
 | 4 | All Saints | Black Coffee |
 | 5 | Melanie B | Tell Me |
 | 6 | Modjo | Lady (Hear Me Tonight) |
 | 7 | Anastacia | I'm Outta Love |
 | 8 | Pink | Most Girls |
 | 9 | Delerium featuring Sarah McLachlan | Silence (Remixes) |
 | 10 | Sugababes | Overload |
 | 11 | DJ Luck & MC Neat featuring JJ | Ain't No Stoppin' Us |
 | 12 | Sonique | Sky |
 | 13 | Sisqo | Unleash The Dragon |
 | 14 | Billie Piper | Something Deep Inside |
 | 15 | Texas | In Demand |
 | 16 | Madonna | Music |
 | 17 | Vanessa Amorosi | Absolutely Everybody |
 | 18 | S Club 7 | Natural |
 | 19 | Whitney Houston / Enrique Iglesias | Could I Have This Kiss Forever |
 | 20 | Sureal | You Take My Breath Away |
 | 21 | Kylie Minogue | On A Night Like This |
 | 22 | Eminem | The Way I Am |
 | 23 | Spiller | Groovejet (If This Ain't Love) |
 | 24 | Roni Size / Reprazent | Who Told You |
 | 25 | Wyclef Jean | It Doesn't Matter |
 | 26 | Robbie Williams | Rock DJ |
 | 27 | Stephen Gately | I Believe |
 | 28 | Placebo | Slave To The Wage |
 | 29 | A1 | Take On Me |
 | 30 | Aurora featuring Naimee Coleman | Ordinary World |
 | 31 | Baha Men | Who Let The Dogs Out |
 | 32 | Element Four | Big Brother UK TV Theme |
 | 33 | Bomfunk MC's | Freestyler |
 | 34 | Monsta Boy featuring Denzie | Sorry (I Didn't Know) |
 | 35 | The Beautiful South | Closer Than Most |
 | 36 | Supersister | Coffee |
 | 37 | True Steppers & Dane Bowers featuring Victoria Beckham | Out Of Your Mind |
 | 38 | Melanie C | I Turn To You |
 | 39 | Scott & Leon | You Used To Hold Me |
 | 40 | Richard Blackwood | 1-2-3-4 Get With The Wicked |