Top 40 Hits of Early April 2006
 | 1 | Ne-Yo | So Sick |
 | 2 | Gnarls Barkley | Crazy |
| 3 | Embrace | Nature's Law |
 | 4 | Orson | No Tomorrow |
| 5 | The Black Eyed Peas | Pump It |
| 6 | Pink | Stupid Girls |
| 7 | The Pussycat Dolls featuring Will I Am | Beep |
| 8 | Corinne Bailey Rae | Put Your Records On |
| 9 | The Kooks | Naive |
| 10 | Mary J Blige & U2 | One |
| 11 | Kanye West featuring Lupe Fiasco | Touch The Sky |
| 12 | Sean Paul | Temperature |
| 13 | Morrissey | You Have Killed Me |
| 14 | Sugababes | Red Dress |
| 15 | Chico | It's Chico Time |
| 16 | The Feeling | Sewn |
| 17 | Madonna | Sorry |
| 18 | The Streets | When You Wasn't Famous |
| 19 | Meck featuring Leo Sayer | Thunder In My Heart Again |
| 20 | The Notorious BIG featuring Diddy, Nelly, Jagged Edge & Avery Storm | Nasty Girl |
| 21 | Beverley Knight | Piece Of My Heart |
| 22 | Joey Negro | Make A Move On Me |
| 23 | Girls Aloud | Whole Lotta History |
| 24 | Ray J | One Wish |
| 25 | Nelly featuring Paul Wall, Ali & Gipp | Grillz |
| 26 | The Source featuring Candi Staton | You Got The Love |
| 27 | Depeche Mode | Suffer Well |
| 28 | Kelly Clarkson | Walk Away |
| 29 | The Yeah Yeah Yeahs | Gold Lion |
| 30 | MVP | Bounce Shake Move Stop |
| 31 | The Zutons | Why Won't You Give Me Your Love? |
| 32 | James Blunt | Wisemen |
| 33 | Massive Attack | Live With Me |
| 34 | The Ordinary Boys | Boys Will Be Boys |
| 35 | Fall Out Boy | Sugar, We're Goin' Down |
| 36 | Chris Brown featuring Juelz Santana | Run It! |
| 37 | Editors | All Sparks |
| 38 | Will Young | All Time Love |
| 39 | Michael Jackson | Bad |
| 40 | Various Artists | Tribute To Jinky |
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